Chemistry Reference
In-Depth Information
Irinotecan [97682-44-55], antineoplastic, topoisomerase inhibitor, 142.
The key inter-
mediate 140 is prepared by phosgenation of 7-ethyl-10-hydroxy-camptothecin 139
[101, 102].
Cl
O
O
HO
COCl
2
O
N
O
N
N
NMe
3
,
N
O
dioxane
O
HO
O
HO
O
139
140
N
H
141
N
N
O
O
N
O
N
O
HO
142
O
Irinotecan
Lenampicillin [86273-18-9], antibacterial, semisynthetic b-lactam antibiotic, derivative of
ampicillin (prodrug for oral application), 145.
The key reagent, the substituted vinyl-
ene carbonate 144, is prepared by the phosgenation of acetoin 143 [103-111].
1.
COCl
2
, NMe
3
2.
D
O
O
O
O
OH
143
144
O
O
O
O
O
O
N
O
S
N
H
H
145
NH
2
Lenampicillin
