Chemistry Reference
In-Depth Information
Tab. 4.7.
Transformation of tert-N-benzylamines into carbamoyl chlorides [135].
Entry
Starting compound
Reaction
time (h)
Yield
(%)
Recovered
starting
material (%)
Ph
1
7
90
2.5
O
N
EtO
Ph
2
7
70
20
N
O
O
Ph
3
N
6
86
0
Ph
4
23
36
26
a
N
Ph
5
5
0
99
N
Ph
6
24
74
7
N
N
Ph
7
24
77
13
N
N
a
in this particular case, the low yield can be attributed to product
instability
H
N
O
O
l
2
O
(COCl)
2
Me
Me
1,2-dichloroethane
24 h, heating
O
Br
O
Br
Br
Br
223
224
Stearoyl carbamoyl chloride 226 has been obtained from stearamide 225 with di-
phosgene in tetrachloromethane [137].
CCl
3
OCOCl
CH
3
(CH
2
)
16
CONH
2
CH
3
(CH
2
)
16
CONHCOCl
CCl
4
225
226
