Deconvolution and Denoising for Confocal Microscopy - Modeling in Computational Biology and Biomedicine - page 112

Chapter 4
Deconvolution and Denoising for Confocal
Microscopy

Praveen Pankajakshan, Gilbert Engler, Laure Blanc-Feraud,
and Josiane Zerubia

4.1 Introduction

4.1.1 The World of Microscopy and Beyond

The appearance of the first microscopes in the late sixteenth century can be
attributed to the fascination and curiosity of man towards the miniature world of
the unseen. The idea of using a lens (originally made to examine fabrics) to look
at small living objects not only revolutionized our view of the living world but also
created the field of biology. Robert Hooke discovered, with his earliest microscope,
that most living organisms are build up of small compartments that he called “Cells”
(because they reminded him of the small rooms where monks lived). This discovery
led to the study of biology and completely changed the way people looked at the
world. Even several generations after this earliest invention, the aesthetic appeal of
the details visible in this tiny microscopic world continues to enamor many.

P. Pankajakshan ( )
Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France
e-mail: [e-mail]
G. Engler
INRA, 400 route des Chappes, 06903 Sophia Antipolis, France
e-mail: [e-mail]
L. Blanc-Feraud
I3S (CNRS/UNS) UMR 7271 CNRS/UNSA and Inria, Algorithmes/Euclide-B,
2000 Route des Lucioles, 06903 Sophia Antipolis, France
e-mail: [e-mail]
J. Zerubia
Inria Sophia Antipolis Mediterranee, Ariana project-team, 2004 Route des Lucioles,
06902 Sophia Antipolis, France
e-mail: [e-mail]