Biomedical Engineering Reference
In-Depth Information
expression of p85alpha: the two sides of a
coin. Diabetes 55:2392-2397
59. Özcan U, Cao Q, Yilmaz E, Lee A-H,
Iwakoshi NN, Ozdelen E, Tuncman G,
Görgün C, Glimcher LH, Hotamisligil GS
(2004) Endoplasmic reticulum stress links
obesity, insulin action, and type 2 diabetes.
Science 306:457-461
60. White MF (2003) Insulin signaling in health
and disease. Science 302:1710-1711
61. Shah OJ, Wang Z, Hunter T (2004)
Inappropriate activation of the TSC/Rheb/
mTOR/S6K cassette induces IRS1/2 deple-
tion, insulin resistance, and cell survival defi-
ciencies. Curr Biol 14:1650-1656
62. Wei Y, Wang D, Topczewski F, Pagliassotti
MJ (2006) Saturated fatty acids induce endo-
plasmic reticulum stress and apoptosis inde-
pendently of ceramide in liver cells. Am J
Physiol Endocrinol Metab 291:E275-E281
63. Wang D, Wei YR, Pagliassotti MJ (2006)
Saturated fatty acids promote endoplasmic
reticulum stress and liver injury in rats
with
71. Lee AH, Scapa EF, Cohen DE, Glimcher LH
(2008) Regulation of hepatic lipogenesis by
the
transcription
factor
XBP1.
Science
320:1492-1496
72. Iqbal J, Dai K, Seimon T, Jungreis R,
Oyadomari M, Kuriakose G, Ron D, Tabas I,
Hussain MM (2008) IRE1b inhibits chylo-
micron production by selectively degrading
MTP mRNA. Cell Metab 7:445-455
73. Butler AE, Janson J, Bonner-Weir S, Ritzel
R, Rizza RA, Butler PC (2003) b-cell deficit
and increased b-cell apoptosis in humans
with type 2 diabetes. Diabetes 52:102-110
74. Song B, Scheuner D, Ron D, Pennathur S,
Kaufman RJ (2008) Chop deletion reduces
oxidative stress, improves b cell function, and
promotes cell survival in multiple mouse
models of diabetes. J Clin Invest 118:
3378-3389
75. Ariyama Y, Shimizu H, Satoh T, Tsuchiya T,
Okada S, Oyadomari S, Mori M (2007)
Chop -deicient mice showed increased adi-
posity but no glucose intolerance. Obesity
(Silver Spring) 15:1647-1656
76. Nozaki J, Kubota H, Yoshida H, Naitoh M,
Goji J, Yoshinaga T, Mori K, Koizumi A,
Nagata K (2004) The endoplasmic reticulum
stress response is stimulated through the
continuous activation of transcription factors
ATF6 and XBP1 in Ins2 +/Akita pancreatic b
cells. Genes Cells 9:261-270
77. Zuber C, Fan JY, Guhl B, Roth J (2004)
Misfolded proinsulin accumulates in
expanded pre-Golgi intermediates and endo-
plasmic reticulum subdomains in pancreatic
beta
hepatic
steatosis.
Endocrinology
147:943-951
64. Bergman RN, Ader M (2000) Free fatty acids
and pathogenesis of type 2 diabetes mellitus.
Trends Endocrinol Metab 11:351-356
65. Haynes CM, Titus EA, Cooper AA (2004)
Degradation of misfolded proteins prevents
ER-derived oxidative stress and cell death.
Mol Cell 15:767-776
66. Harding HP, Zhang Y, Zeng H, Novoa I, Lu
PD, Calfon M, Sadri N, Yun C, Popko B,
Paules R, Stojdl DF, Bell JC, Hettmann T,
Leiden JM, Ron D (2003) An integrated
stress response regulates amino acid metabo-
lism and resistance to oxidative stress. Mol
Cell 11:619-633
67. Kamata H, Honda S, Maeda S, Chang L,
Hirata H, Karin M (2005) Reactive oxygen
species promote TNFa-induced death and
sustained JNK activation by inhibiting MAP
kinase phosphatases. Cell 120:649-661
68. Örd D, Örd T (2005) Characterization of
human NIPK ( TRB3 , SKIP3 ) gene activa-
tion in stressful conditions. Biochem Biophys
Res Commun 330:210-218
69. Ohoka N, Yoshii S, Hattori T, Onozaki K,
Hayashi H (2005) TRB3, a novel ER stress-
inducible gene, is induced via ATF4-CHOP
pathway and is involved in cell death. EMBO
J 24:1243-1255
70. Du K, Herzig S, Kulkarni RN, Montminy M
(2003) TRB3: a tribbles homolog that inhib-
its Akt/PKB activation by insulin in liver.
Science 300:1574-1577
cells
of
Akita
mice.
FASEB
J 18:U341-U360
78. Wang J, Takeuchi T, Tanaka S, Kubo SK,
Kayo T, Lu D, Takata K, Koizumi A, Izumi
T (1999) A mutation in the insulin 2 gene
induces diabetes with severe pancreatic b-cell
dysfunction in the Mody mouse. J Clin Invest
103:27-37
79. Herbach N, Rathkolb B, Kemter E, Pichl L,
Klaften M, de Angelis MH, Halban PA, Wolf
E, Aigner B, Wanke R (2007) Dominant-
negative effects of a novel mutated Ins2 allele
causes early-onset diabetes and severe beta-
cell loss in Munich Ins2 C95S mutant mice.
Diabetes 56:1268-1276
80. Oyadomari S, Koizumi A, Takeda K, Gotoh
T, Akira S, Araki E, Mori M (2002) Targeted
disruption of the Chop gene delays endoplas-
mic
reticulum
stress-mediated
diabetes.
J Clin Invest 109:525-532
81. Colombo C, Porzio O, Liu M, Massa O,
Vasta M, Salardi S, Beccaria L, Monciotti C,
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