Biomedical Engineering Reference
In-Depth Information
usually keeps this solution refrigerated in a 10 ml syringe
with the outlet wrapped completely in wax paper.
21. Electron-micrographs of mitochondrial alterations under var-
ious conditions.
Acknowledgments
This work was supported by a Grant-in-Aid for General Scientific
Research (C) from The Ministry of Education, Culture, Sports,
Science and Technology of Japan.
References
1. Hirano A (ed) (1981) A guide to neuropa-
thology. Igaku-Shoin, New York, USA, pp.
154-157
2. Ross, M. H. and Pawlina, W. (eds.) (2006)
Mitochondria, 2 the cell cytoplasm. Membra-
nous organelles, in Histology. A text and atlas.
With correlated cell and molecular biology,
5th ed., Lippincott Williams & Wilkins, USA,
pp. 52-54
3. Nikali K, Suomalainen A, Saharinen J,
Kuokkanen M, Spelbrink JN, Lönnqvist T
et al (2005) Infantile onset spinocerebellar
ataxia is caused by recessive mutations in
mitochondrial proteins Twinkle and Twinky.
Hum Mol Genet 14:2981-2990
4. Comi GP, Bordoni A, Salani S, Franceschina L,
Sciacco M, Prelle A et al (1998) Cytochrome c
oxidase submit I microdeletion in a patient with
motor neuron disease. Ann Neurol 43:110-116
5. Orth M, Schapira AH (2001) Mitochondria
and degenerative disorders. Am J Med Genet
106:27-36
6. Sasaki S, Iwata M (1996) Ultrastructural
study of synapses in the anterior neurons of
patients with amyotrophic lateral sclerosis.
Neurosci Lett 204:53-56
7. Siklos L, Engelhardt J, Harati Y, Smith RG,
Joo F, Appel SH (1996) Ultrastructural
evidence for altered calcium in motor nerve
terminals in amyotrophic lateral sclerosis. Ann
Neurol 39:203-216
8. Wiedemann FR, Manfredi G, Mawrin C,
Beal MF, Schon EA (2002) Mitochondrial
DNA and respiratory chain function in
spinal cords of ALS patients. J Neurochem
80:616-625
9. Bowling AC, Schulz JB, Brown RH, Beal
MF (1993) SOD activity, oxidative damage,
and mitochondrial energy metabolism in
familial and sporadic ALS. J Neurochem
61:2322-2325
10. Dhaliwal GK, Grewall RP (2000)
Mitochondrial DNA deletion mutation levels
are elevated in ALS brains. Neuroreport
11:2507-2509
11. Kong J, Xu Z (1998) Massive mitochondrial
degeneration in motor neurons triggers the
onset of amyotrophic lateral sclerosis in mice
expressing a mutant SOD1. J Neurosci
18:3241-3250
12. Wong PC, Pardo CA, Borchelt DR, Lee MK,
Copeland NG, Jenkins NA et al (1995) An
adverse property of a familial ALS-linked
SOD1 mutation causes motor neuron disease
characterized by vacuolar degeneration of
mitochondria. Neuron 14:1105-1116
Search WWH ::




Custom Search