Environmental Engineering Reference
In-Depth Information
A
mem
.
Membrane.surface.area
[C]
GI
.
Solute.concentration.within.the.GI.tract
[C]
IC
.
Solute.concentration.in.the.GI.epithelium.cell
[C]
CC
.
Solute.concentration.within.the.central.compartment
[C
0
].
Initial.concentration
D
Diffusion.coeficient
D
mem
Diffusion.coeficient.of.the.membrane
d
mem
Diffusion.distance.or.membrane.thickness
CS
Y
Cross-sectional.area.of.the.airway.at.point.y
dc
Concentration.gradient
dx
Distance.across.the.concentration.gradient
dn
1
/dt
.
Rate.of.solute.lux.from.GI.tract.to.GI.epithelial.cell
dn
2
/dt
.
Rate.of.solute.lux.from.GI.epithelial.cell.to.the.central.compartment
dC/dx
Concentration.gradient
dy
Ininitesimal.of.the.change.in.longitudinal.position.within.the.airway
J
Flux.rate
J
mem
Flux.rate.across.the.membrane.boundary
k
Boltzmann.constant
k
ow
Octanol-water.partition.coeficient
k
mem
Partition.coeficient. of. a. solute. between. an. aqueous. solution/suspension.
and.a.membrane.solution/suspension
n
Number.of.particles
P
Permeability
P
v-o
Theoretical.zero-volume.permeability
r
p
Radius.of.the.nanoparticle
r
a
Radius
T
Absolute.temperature
v-
Air.low.velocity
V
Molecular.volume
y
Hypothetical.point
η.
Viscosity.of.the.aerosol
ReFeRenCes
.
1.. McCash,.E.M..2001..
Surface Chemistry.
.Oxford:.Oxford.University.Press.
.
2.. Freeman,.H.J..and.A.B.R..Thomson..2000..Small.intestine..In.
First Principals of Gas-
troenterology: The Basis of Disease and an Approach to Management,
. 4th. edition,.
Eds..A.B.R..Thompson.and.E.A..Shaffer,.p..175-257..Edmonton,.AB:.Astra.
.
3.. Lieb,.W.R..and.W.D..Stein..1986..Non-Stokesian.nature.of.transverse.diffusion.within.
human.red.cell.membranes..
J. Membrane Biol.,
.92:111-119.
.
4.. Sherrill,. B.C.. and. J.M.. Dietschy.. 1978.. Characterization. of. the. sinusoidal. trans-
port. process. responsible. for. uptake. of. chylomicrons. by. the. liver..
J. Biolog. Chem..
.
253:1859-1867.
.
5.. Jani,.P.,.G.W..Halbert,.J..Langridge,.and.A.T..Florence..1990..Nanoparticle.uptake.by.
rat.gastrointestinal.mucosa:.quantitation.and.particle.size.dependency..
J. Pharm. Phar-
macol.,
.42:821-826.
