Environmental Engineering Reference
In-Depth Information
Mice
Single-walled.carbon.
nanotubes
1-4.nm
Acute:.10-40.µg/
mouse,.single.
intrapharyngeal.
instillation.(sacriiced.
at.1,.7,.28,.and.56.
days.post.exposure).
Chronic:.20.µg/
mouse,.pharyngeal.
aspiration,.once.every.
other.week.for.8.
weeks.(mice.in.this.
group.are.bred.with.
elevated.cholesterol.
levels.and.were.fed.a.
high-fat.diet).
Aortic.
mitochondria.
(oxidative.stress.
assays)
Aortic.mitochondrial.DNA.
damage.at.7,.28,.and.60.days.
post.exposure..Increase.in.
atherosclerosis.plaque.
formation.reported.in.
chronically.treated.mice.
Results.indicate.that.
respiratory.exposure.to.
SWCNTs.might.accelerate.
the.development.of.
atherosclerosis.and.be.
associated.with.
cardiovascular.adverse.
effects.
[47]
Guinea.pig.alveolar.
macrophages
SWCNTs,.
MWCNT10,.and.
fullerene.(C60)
1.4.nm.(SWCNT)
10-20.nm.
(MWCNT10)
C60.—.not.
provided
SWCNT.and.C60:.0,.
1.41,.2.82,.5.65,.
11.30,.28.20,.56.50,.
113.00,.and.226.0.µg/
cm 2 .MWCNT10:.0,.
1.41,.2.82,.5.65,.
11.30,.and.22.60.
µg/cm 2
Cytotoxicity
SWCNT:.high.cytotoxicity.at.
lowest.dose;.for.MWCNT10,.
cytotoxic.effects.but.at.the.
highest.dose...C60.did.not.
induce.cytotoxicity.at.any.
concentration.
Results.suggest.that.toxicity.of.
nanomaterials.increases.with.
an.increase.in.surface.area.
[34]
Mice.(B6C3F 1 )
SWCNT,.Carbon.
black
1.nm
Single.dose.of.0,.0.1,.
or.0.5.mg/mouse.
intratracheally.
instilled;.euthanized.
7.and.90.days.post.
treatment
Cytotoxicity/lung
SWCNT:.Dose-dependent.
epithelioid.granulomas,.
interstitial.inlammation,.
peribronchial.inlammation,.
necrosis..Lesions.more.
persistent.and.pronounced.in.
90-day.group..Carbon.black:.
no.lung.adverse.effects.
Results.suggest.that.toxicity.of.
nanomaterials.increases.with.
an.increase.in.surface.area.
[23]
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