The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine - RNA Interference from Biology to Therapeutics - page 63

Table 3.1 miRNAs involved in osteogenesis and adipogenesis
Effect

miRNA Cell type Species Target Reference

Pro-osteogenic miR-20a BMSC Human PPAR g BAMBI CRIM1 [ 33 ]

Pro-osteogenic miR-20b BMSC Human PPAR g BAMBI CRIM1 [ 34 ]

Anti-osteogenic
( fi nal stage)

miR-26a ADSC Human SMAD1 [ 35 ]

Anti-osteogenic mi-27a BMSC Human GCA [ 36 ]

Anti-osteogenic miR-138 BMSC Human FAK [ 5 ]

Pro-osteogenic miR-146a Periodontal

ligament cells

Human NF- k B [ 37 ]

Pro-osteogenic miR-148b BMSC Human N/A [ 36 ]

Pro-osteogenic miR-196a ADSC Human HOXC8 [ 38 ]

Anti-osteogenic miR-489 BMSC Human GCA [ 36 ]

Pro-osteogenic miR-29b Rat calvaria

osteoblasts,
MC3T3

Mouse rat COL1A1 COL5A3

COL4A2 HDAC4
TGFb 3 ACVR2A
CTNNBIP1 DUSP2

[ 39 ]

Anti-osteogenic miR-125b ST2 Mouse ERBB2 [ 40 ]

Anti-osteogenic miR-133 C2C12 Mouse RUNX2 [ 41 ]

Anti-osteogenic miR-135 C2C12 Mouse SMAD5 [ 41 ]

Pro-osteogenic miR-141 MC3T3-E1 Mouse DLX5 [ 42 ]

Pro-osteogenic miR-200a MC3T3-E1 Mouse DLX5 [ 42 ]

Anti-osteogenic miR-206 C2C12, primary

osteoblasts

Mouse Connexin 43 [ 43 ]

Pro-osteogenic miR-210 ST2 Mouse ACVR1b [ 44 ]

Pro-osteogenic miR-2861 Primary osteo-

blasts, ST2

Mouse HDAC5 [ 45 ]

Anti-adipogenic miR-27b ADSC Human PPAR g [ 46 ]

Pro-adipogenic miR-30 ADSC Human RUNX2 [ 47 ]

Anti-adipogenic miR-130 Primary

pre-adipocytes

Human PPAR g [ 48 ]

Anti-adipogenic miR-138 ADSC Human EID-1 [ 49 ]

Pro-adipogenic miR-143 Pre-adipocytes Human ERK5 [ 50 ]

Anti-adipogenic miR-155 BMSC Human N/A [ 51 ]

Anti-adipogenic miR-221 BMSC Human CDKN1B [ 51 ]

Anti-adipogenic miR-222 BMSC Human CDKN1B [ 51 ]

Pro-adipogenic miR-642-3p ADSC Human N/A [ 47 ]

Anti-adipogenic miR-369-5p BMSC Human FABP4 [ 52 ]

Pro-adipogenic miR-371 BMSC Human N/A [ 52 ]

Pro-adipogenic miR-17-92

cluster

3T3-L1 Mouse RB2/P130 [ 53 ]

Anti-adipogenic miR-31 C3H10T1/2 Mouse CEBPA [ 54 ]

Anti-adipogenic miR-27a/b 3T3-L1, OP9 Mouse PPAR g [ 55 ]

Pro-adipogenic miR-103 3T3-L1 Mouse N/A [ 56 ]

Pro-adipogenic miR-200 ST2 Mouse N/A [ 57 ]

Pro-adipogenic miR-204/211 ST2 Mouse RUNX2 [ 58 ]

Pro-adipogenic miR378/378* ST2 Mouse N/A [ 59 ]