Biology Reference
In-Depth Information
173. Zhang Z, Weinschenk T, Guo K, Schluesener HJ (2006) siRNA binding proteins of
microglial cells: PKR is an unanticipated ligand. J Cell Biochem 97:1217-1229
174. Marques JT, Devosse T, Wang D, Zamanian-Daryoush M, Serbinowski P, Hartmann R, Fujita
T, Behlke MA, Williams BR (2006) A structural basis for discriminating between self and
nonself double-stranded RNAs in mammalian cells. Nat Biotechnol 24:559-565
175. Puthenveetil S, Whitby L, Ren J, Kelnar K, Krebs JF, Beal PA (2006) Controlling activation
of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification.
Nucleic Acids Res 34:4900-4911
176. Sledz CA, Holko M, de Veer MJ, Silverman RH, Williams BR (2003) Activation of the inter-
feron system by short-interfering RNAs. Nat Cell Biol 5:834-839
177. Birmingham A, Anderson EM, Reynolds A, Ilsley-Tyree D, Leake D, Fedorov Y, Baskerville
S, Maksimova E, Robinson K, Karpilow J et al (2006) 3¢ UTR seed matches, but not overall
identity, are associated with RNAi off-targets. Nat Methods 3:199-204
178. Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS,
Johnson JM (2005) Microarray analysis shows that some microRNAs downregulate large
numbers of target mRNAs. Nature 433:769-773
179. Jackson AL, Burchard J, Leake D, Reynolds A, Schelter J, Guo J, Johnson JM, Lim L,
Karpilow J, Nichols K et al (2006) Position-specific chemical modification of siRNAs
reduces “off-target” transcript silencing. RNA 12:1197-1205
180. Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K (2008)
Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA
with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly
reduced off-target effect. Nucleic Acids Res 36:2136-2151
181. Chen PY, Weinmann L, Gaidatzis D, Pei Y, Zavolan M, Tuschl T, Meister G (2008) Strand-
speci fi c 5 ¢-O-methylation of siRNA duplexes controls guide strand selection and targeting
speci fi city. RNA 14:263-274
182. Vaish N, Chen F, Seth S, Fosnaugh K, Liu Y, Adami R, Brown T, Chen Y, Harvie P, Johns R
et al (2011) Improved specificity of gene silencing by siRNAs containing unlocked nucle-
obase analogs. Nucleic Acids Res 39:1823-1832
183. Khan AA, Betel D, Miller ML, Sander C, Leslie CS, Marks DS (2009) Transfection of small
RNAs globally perturbs gene regulation by endogenous microRNAs. Nat Biotechnol
27:549-555
184. Hasuwa H, Kaseda K, Einarsdottir T, Okabe M (2002) Small interfering RNA and gene
silencing in transgenic mice and rats. FEBS Lett 532:227-230
185. Seibler J, Kuter-Luks B, Kern H, Streu S, Plum L, Mauer J, Kuhn R, Bruning JC, Schwenk F
(2005) Single copy shRNA configuration for ubiquitous gene knockdown in mice. Nucleic
Acids Res 33:e67
186. Kunath T, Gish G, Lickert H, Jones N, Pawson T, Rossant J (2003) Transgenic RNA interfer-
ence in ES cell-derived embryos recapitulates a genetic null phenotype. Nat Biotechnol
21:559-561
187. Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Rooney DL, Ihrig
MM, McManus MT, Gertler FB et al (2003) A lentivirus-based system to functionally silence
genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat
Genet 33:401-406
188. Tiscornia G, Singer O, Ikawa M, Verma IM (2003) A general method for gene knockdown in
mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci U S A
100:1844-1848
189. Klinghoffer RA, Magnus J, Schelter J, Mehaffey M, Coleman C, Cleary MA (2010) Reduced
seed region-based off-target activity with lentivirus-mediated RNAi. RNA 16:879-884
190. Yuan MK, Tao Y, Yu WZ, Kai W, Jiang YR (2010) Lentivirus-mediated RNA interference of
vascular endothelial growth factor in monkey eyes with iris neovascularization. Mol Vis
16:1743-1753
191. Liu YP, Vink MA, Westerink JT, Ramirez de Arellano E, Konstantinova P, Ter Brake O,
Berkhout B (2010) Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by
different mechanisms that require distinct repair strategies. RNA 16:1328-1339
Search WWH ::
Custom Search