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116. Fisher M, Abramov M, Van Aerschot A, Xu D, Juliano RL, Herdewijn P (2007) Inhibition of
MDR1 expression with altritol-modified siRNAs. Nucleic Acids Res 35:1064-1074
117. Nauwelaerts K, Fisher M, Froeyen M, Lescrinier E, Aerschot AV, Xu D, DeLong R, Kang H,
Juliano RL, Herdewijn P (2007) Structural characterization and biological evaluation of small
interfering RNAs containing cyclohexenyl nucleosides. J Am Chem Soc 129:9340-9348
118. Deleavey GF, Watts JK, Alain T, Robert F, Kalota A, Aishwarya V, Pelletier J, Gewirtz AM,
Sonenberg N, Damha MJ (2010) Synergistic effects between analogs of DNA and RNA improve
the potency of siRNA-mediated gene silencing. Nucleic Acids Res 38(13): 4547-4557
119. Elmén J, Thonberg H, Ljungberg K, Frieden M, Westergaard M, Xu Y, Wahren B, Liang Z,
Ørum H, Koch T et al (2005) Locked nucleic acid (LNA) mediated improvements in siRNA
stability and functionality. Nucleic Acids Res 33:439-447
120. Sipa K, Sochacka E, Kazmierczak-Baranska J, Maszewska M, Janicka M, Nowak G, Nawrot
B (2007) Effect of base modifications on structure, thermodynamic stability, and gene silenc-
ing activity of short interfering RNA. RNA 13:1301-1316
121. Li ZY, Mao H, Kallick DA, Gorenstein DG (2005) The effects of thiophosphate substitutions
on native siRNA gene silencing. Biochem Biophys Res Commun 329:1026-1030
122. Strapps WR, Pickering V, Muiru GT, Rice J, Orsborn S, Polisky BA, Sachs A, Bartz SR
(2010) The siRNA sequence and guide strand overhangs are determinants of in vivo duration
of silencing. Nucleic Acids Res 38:4788-4797
123. Bramsen JB, Pakula MM, Hansen TB, Bus C, Langkjaer N, Odadzic D, Smicius R, Wengel
SL, Chattopadhyaya J, Engels JW et al (2010) A screen of chemical modifications identifies
position-specific modification by UNA to most potently reduce siRNA off-target effects.
Nucleic Acids Res 38:5761-5773
124. Laursen MB, Pakula MM, Gao S, Fluiter K, Mook OR, Baas F, Langklaer N, Wengel SL,
Wengel J, Kjems J et al (2010) Utilization of unlocked nucleic acid (UNA) to enhance siRNA
performance in vitro and in vivo. Mol Biosyst 6:862-870
125. Odadzic D, Bramsen JB, Smicius R, Bus C, Kjems J, Engels JW (2008) Synthesis of
2¢-O-modified adenosine building blocks and application for RNA interference. Bioorg Med
Chem 16:518-529
126. Bramsen JB, Kjems J (2011) Chemical modification of small interfering RNA. Methods Mol
Biol 721:77-103
127. Gao S, Dagnaes-Hansen F, Nielsen EJ, Wengel J, Besenbacher F, Howard KA, Kjems J
(2009) The effect of chemical modification and nanoparticle formulation on stability and
biodistribution of siRNA in mice. Mol Ther 17:1225-1233
128. Goodchild A, Nopper N, King A, Doan T, Tanudji M, Arndt GM, Poidinger M, Rivory LP,
Passioura T (2009) Sequence determinants of innate immune activation by short interfering
RNAs. BMC Immunol 10:40
129. Sioud M (2006) Single-stranded small interfering RNA are more immunostimulatory than
their double-stranded counterparts: a central role for 2¢-hydroxyl uridines in immune
responses. Eur J Immunol 36:1222-1230
130. Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, Noronha A,
Manoharan M, Akira S, de Fougerolles A et al (2005) Sequence-specific potent induction of
IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med
11:263-270
131. Chiu YL, Rana TM (2003) siRNA function in RNAi: a chemical modification analysis. RNA
9:1034-1048
132. Amarzguioui M, Holen T, Babaie E, Prydz H (2003) Tolerance for mutations and chemical
modifications in a siRNA. Nucleic Acids Res 31:589-595
133. Choung S, Kim YJ, Kim S, Park HO, Choi YC (2006) Chemical modification of siRNAs to
improve serum stability without loss of efficacy. Biochem Biophys Res Commun 342:919-927
134. Harborth J, Elbashir SM, Vandenburgh K, Manninga H, Scaringe SA, Weber K, Tuschl T
(2003) Sequence, chemical, and structural variation of small interfering RNAs and short hair-
pin RNAs and the effect on mammalian gene silencing. Antisense Nucleic Acid Drug Dev
13:83-105
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