Biology Reference
In-Depth Information
53. Bader AG, Brown D, Winkler M (2010) The promise of microRNA replacement therapy.
Cancer Res 70:7027-7030
54. Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M, Stoffel M (2005)
Silencing of microRNAs in vivo with 'antagomirs'. Nature 438:685-689
55. Stenvang J, Petri A, Lindow M, Obad S, Kauppinen S (2012) Inhibition of microRNA func-
tion by antimiR oligonucleotides. Silence 3:1
56. Elmen J, Lindow M, Schutz S, Lawrence M, Petri A, Obad S, Lindholm M, Hedtjarn M,
Hansen HF, Berger U et al (2008) LNA-mediated microRNA silencing in non-human pri-
mates. Nature 452:896-899
57. Ameres SL, Horwich MD, Hung JH, Xu J, Ghildiyal M, Weng Z, Zamore PD (2010) Target
RNA-directed trimming and tailing of small silencing RNAs. Science 328:1534-1539
58. Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, van Gils JM, Ray TD,
Sheedy FJ, Goedeke L, Liu X et al (2011) Inhibition of miR-33a/b in non-human primates
raises plasma HDL and lowers VLDL triglycerides. Nature 478:404-407
59. Ebert MS, Neilson JR, Sharp PA (2007) MicroRNA sponges: competitive inhibitors of small
RNAs in mammalian cells. Nat Methods 4:721-726
60. Ebert MS, Sharp PA (2010) Emerging roles for natural microRNA sponges. Curr Biol
20:R858-R861
61. Merkel OM, Librizzi D, Pfestroff A, Schurrat T, Behe M, Kissel T (2009) In vivo SPECT and
real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery
using an optimized radiolabeling and purification procedure. Bioconjug Chem 20:174-182
62. Jackson AL, Bartz SR, Schelter J, Kobayashi SV, Burchard J, Mao M, Li B, Cavet G, Linsley
PS (2003) Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol
21:635-637
63. Jackson AL, Burchard J, Schelter J, Chau BN, Cleary M, Lim L, Linsley PS (2006) Widespread
siRNA “off-target” transcript silencing mediated by seed region sequence complementarity.
RNA 12:1179-1187
64. Judge AD, Sood V, Shaw JR, Fang D, McClintock K, MacLachlan I (2005) Sequence-
dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat
Biotechnol 23:457-462
65. Kariko K, Bhuyan P, Capodici J, Weissman D (2004) Small interfering RNAs mediate
sequence-independent gene suppression and induce immune activation by signaling through
toll-like receptor 3. J Immunol 172:6545-6549
66. Cirak S, Arechavala-Gomeza V, Guglieri M, Feng L, Torelli S, Anthony K, Abbs S, Garralda
ME, Bourke J, Wells DJ et al (2011) Exon skipping and dystrophin restoration in patients
with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer
treatment: an open-label, phase 2, dose-escalation study. Lancet 378:595-605
67. Monia BP, Lesnik EA, Gonzalez C, Lima WF, McGee D, Guinosso CJ, Kawasaki AM, Cook
PD, Freier SM (1993) Evaluation of 2¢ -modi fi ed oligonucleotides containing 2 ¢ -deoxy gaps
as antisense inhibitors of gene expression. J Biol Chem 268:14514-14522
68. Gupta N, Fisker N, Asselin MC, Lindholm M, Rosenbohm C, Orum H, Elmen J, Seidah NG,
Straarup EM (2010) A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9
and enhances LDLR expression in vitro and in vivo. PLoS One 5:e10682
69. Tanudji M, Machalek D, Arndt GM, Rivory L (2009) Competition between siRNA duplexes:
impact of RISC loading efficiency and comparison between conventional-21 bp and Dicer-
substrate siRNAs. Oligonucleotides 20:27-32
70. Siolas D, Lerner C, Burchard J, Ge W, Linsley PS, Paddison PJ, Hannon GJ, Cleary MA
(2005) Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol 23:227-231
71. Kim DH, Behlke MA, Rose SD, Chang MS, Choi S, Rossi JJ (2005) Synthetic dsRNA Dicer
substrates enhance RNAi potency and efficacy. Nat Biotechnol 23:222-226
72. Amarzguioui M, Lundberg P, Cantin E, Hagstrom J, Behlke MA, Rossi JJ (2006) Rational
design and in vitro and in vivo delivery of Dicer substrate siRNA. Nat Protoc 1:508-517
73. Hefner E, Clark K, Whitman C, Behlke MA, Rose SD, Peek AS, Rubio T (2008) Increased
potency and longevity of gene silencing using validated Dicer substrates. J Biomol Tech
19:231-237
Search WWH ::




Custom Search