Biology Reference
In-Depth Information
Table 13.3
Circulating miRNAs
Tumor type
MicroRNAs
Signi fi cance
References
Biliary tract cancer
miR-9
Diagnosis; stable in bile
[
200
]
Bladder cancer
miR-126 and miR-182
Upregulated in urine; diagnosis
[
201
]
miR-96 and miR-183
Diagnosis (urine)
[
202
]
Breast cancer
miR-195 and let-7a; miRNA-21, 106a, 126,
155, 199a and 335
Correlated with nodal status and estrogen receptor
status, and decreased postoperatively
[
203,
204
]
Colorectal carcinoma
miR-92; miR-29and miR-92a
Diagnosis with 70% specificity and 89% sensitiv-
ity; early detection of CRC
[
190,
205
]
Diffuse large B-cell
lymphoma
miR-21
Relapse-free survival
[
153
]
Glioblastoma
miR-21
Upregulated in serum microvesicles
[
179
]
Gastric cancer
miR-17-5p, miR-21, miR-106a, miR-106b, let-7a;
miR-1, miR-20a, miR-27a, miR-34 and miR-423-5p
Up- or downregulated; correlated to tumor stage
[
206,
207
]
Hepatocellular carcinoma
miR-92a; miR-500; miR-25, miR-375, and let-7f
Downregulated, upregulated after surgical
treatment, and diagnosis
[
208-
210
]
Leukemia
miR-92a/miR-638; miR-29a, -181a, and -221
Diagnosis and treatment
[
211,
212
]
Melanoma
Gene pro fi les
21 miRNAs downregulated/30 miRNAs
upregulated
[
213
]
Multiple melanoma
miR-193b-365
Upregulated
[
214
]
Non-small cell lung
carcinoma
miR-25 and miR-223; exosomal miRNA;
miR-486, miR-30d, miR-1, and miR-499
Upregulated; screening test; overall survival
[
156,
197,
215
]
Oral cancer
miR-31; miR-184
Upregulated, and downregulated after surgical
resection; diagnosis
[
216,
217
]
Ovarian cancer
miRNAs-21, 92, 93, 126, and 29a;
miRNAs-155, 127, and 99b
Upregulated, and related with pre-operative
CA-125; downregulated; exosomes
[
166,
218,
219
]
Pancreatic cancer
miR-21, miR-210, miR-155, and miR-196a
Diagnosis
[
220-
223
]
Prostate cancer
miR-141
Diagnosis
[
155
]
Esophageal squamous
cell carcinoma
miR-10a, miR-22, miR-100, miR-148b, miR-223,
miR-133a, and miR-127-3p
Upregulated
[
224
]
Rhabdomyosarcoma
miR-206
Upregulated
[
225
]
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