Biology Reference
In-Depth Information
Table 13.1
Commonly deregulated miRNAs in human malignancies
Tumor suppressor (TS)
or oncomiR (OM)
miRNA
Expression in cancer
Validated targets
References
let-7 family
↓: Breast, CLL, colon, gastric, leiomyoma,
lung, melanoma, ovarian, prostate
TS
CDK6, CDC25A, E2F2,
HMGA2, c-MYC, RAS
[
4,
7,
13-
20
]
miR-15a/16-1
cluster
↓: CLL, lymphoma, multiple myeloma,
pancreatic, pituitary adenoma, prostate
TS
BCL2, MAGE83, WT1
[
6,
13,
21-
24
]
miR-17-92
cluster
↑: Breast, colon, gastric, lung, lymphoma,
medulloblastoma, multiple myeloma,
pancreatic, prostate
OM
BIM, E2F1, PTEN
[
14,
16,
18,
25-
31
]
miR-21
↑: AML, breast, cervical, CLL, colon, gastric,
glioblastoma, head and neck, lung,
myeloma pancreatic, prostate
OM
PDCD4, PTEN, TPM1
[
4,
14,
16,
25,
32-
39
]
miR-29
↓: Breast, CLL, liver, lung, lymphoma
TS
DNMT1, DNMT3a/b, MCL1,
TCL1
[
12,
14,
25,
32,
40-
43
]
miR-34a/b/c
↓: Breast, bladder, CLL, colon, glioblastoma,
kidney, liver, lymphoma, neuroblastoma,
pancreatic
TS
BCL2, CDK4, CDK6, CREB,
cyclin E2, E2F3, MET
[
8,
13,
32,
35,
44-
52
]
miR-145
↓: Bladder, breast, prostate
TS
CBFB, ERG, SWAP70
[
14,
53,
54
]
miR-155
↑: AML, breast, CLL, colon, lung, lymphoma,
pancreatic
OM
AID, SHIP1
[
13,
14,
16,
25,
32-
34,
55-
58
]
miR-221/222
cluster
↑: CLL, glioblastoma, liver, thyroid carcinoma.
↓: Erythroblastic leukemia, prostate
TS/OM
KIT, PTEN, p27, p57, TIMP3
[
59-
65
]
AID
activation induced cytidine deaminase,
AML
acute myeloid leukemia,
BCL2
B-cell leukemia/lymphoma 2,
BIM
Bcl2-interacting mediator of cell death,
CBFB
core-binding factor b subunit,
CDC25A
cell division cycle 25 homolog A,
CDK4
cyclin-dependent kinase 4,
CDK6
cyclin-dependent kinase 6,
CLL
chronic lymphocytic leukemia,
c-MYC
v-myc avian myelocytomatosis viral oncogene homolog,
CREB
cAMP responsive element binding protein,
DNMT
DNA methyltransferase,
E2F1/2/3
E2F transcription factor 1/2/3,
ERG
ETS-related gene,
HMGA2
high mobility group AT-hook 2,
KIT
tyrosine kinase recep-
tor,
MAGE83
melanoma antigen family 83,
MCL1
myeloid cell leukemia sequence 1,
MET
met proto-oncogene (hepatocyte growth factor receptor),
PDCD4
programmed cell death 4,
PTEN
phosphatase and tensin homolog,
RAS
rat sarcoma oncogenes (protein subfamily of small GTPases),
SHIP1
SH2 domain-
containing inositol-5¢-phosphatase 1,
SWAP70
SWAP switching B-cell complex 70 kDa subunit,
TCL1
T-cell lymphoma breakpoint 1,
TIMP3
tissue inhibitor
of metalloproteinases 3,
TPM1
tropomyosin 1,
WT1
Wilms tumor 1
Search WWH ::
Custom Search