Biomedical Engineering Reference
In-Depth Information
section
22.3.2
showed good agreement with
in vitro
PCC data on simple exchanges
induced in human lymphocytes exposed to Carbon and Iron ions. This provided
further support for the main assumption of the model, i.e. that aberrations arise from
clustered, and thus severe, double-helix breaks. In progress for this model is also the
implementation of chromosome aberration processing at mitosis, which determines
whether the cell will fail duplication or it will be able to duplicate possibly giving
rise to aberrated daughter cells. This is a key issue in radiobiology because on one
side the duplication of aberrated cells implies an enhanced risk for normal tissue
with possible consequences in terms of radiation protection, whereas on the other
side the death of (tumour) cells is the main goal for radiotherapy.
Acknowledgements
This work was partially supported by EU (“RISC-RAD” project, Contract
no. FI6R-CT-2003-508842, and “NOTE” project, Contract no. FI6R-036465) and ASI (Italian
Space Agency, “Mo-Ma/COUNT” project).
References
1. Savage J, Simpson P, Mutat Res
312
, 51-60 (1994)
2. Durante M, Furusawa Y, Gotoh E, Int J Radiat Biol
74
, 457-462 (1998)
3. Pinkel D, Straume T, Gray J., Proc Natl Acad Sci USA
83
, 2934-2938 (1986)
4. Cornforth M, Radiat Res
155
, 643-659 (2001)
5. Anderson R, Stevens D, Goodhead D, Proc Natl Acad Sci USA
99
, 12167-12172 (2002)
6. Mitelman F, Mutat Res
462
, 247-253 (2000)
7. de The H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A, Cell
66
, 675-684 (1991)
8. Faretta MR, Di Croce L, Pelicci PG, Seminars in Hematology
38
, 42-53 (2001)
9. Bonassi S, Hagmar L, Stromberg U, Huici Montagud A, Tinnerberg H, Forni A, Heikkila P,
Wanders S, Norppa H, for the European Study Group on Cytogenetic Biomarkers and Health
(ESCH), Cancer Res
60
, 1619-1625 (2000)
10. Durante M, Radiat Res
164
, 467-473 (2005)
11. Bauchinger M, Schmid E, Braselmann H, Int J Radiat Biol
77
, 553-557 (2001)
12. Sakamoto-Hojo E, Natarajan AT, Curado MP, Radiat Prot Dosim
86
, 25-32 (1999)
13. Kanda R, Minamihisamatsu M, Hayata I, Int J Radiat Biol
78
, 857-862 (2002)
14. Hsieh W, Lucas JN, Hwang JJ, Chan CC, Chang WP, Int J Radiat Biol
77
, 797-804 (2001)
15. Lindholm C, Tekkel M, Veidebaum T et al, Int J Radiat Biol
74
, 565-571 (1998)
16. Lloyd D, Moquet JE, Oram S, Edwards AA, Lucas JN, Int J Radiat Biol
73
, 543-547 (1998)
17. Johnson K, Nath J et al., Mutat Res
439
, 77-85 (1999)
18. Snigiryova G, Braselmann H, Salassidis K et al, Int J Radiat Biol
71
, 119-127 (1997)
19. Stephan G, Pressl S, Int J Radiat Biol
71
, 293-299 (1997)
20. Stram D, Sposto R et al, Radiat Res
136
, 29-36 (1993)
21. Nakano M, Kodama Y et al, Int J Radiat Biol
77
, 971-977 (2001)
22. George K, Durante M, Wu H, Willingham V, Badhwar G, Cucinotta F, Radiat Res
156
,
731-738 (2001)
23. Yang T, George K, Johnson AS, Durante M, Fedorenko BS, Biodosimetry results from space
flight MIR-18 Radiat Res
148
, S17-S23 (1997)
24. Obe G, Johannes I, Johannes C, Hallman K, Reiz G, Facius R, Int J Radiat Biol
72
,
727-734 (1997)
25. Testard I, Ricoul M, Hoffschir F, Flury-Herard A, Dutrillaux B, Fedorenko B, Gerasimenko V,
Sabatier L, Int J Radiat Biol
70
, 403-411 (1996)
