Biology Reference
In-Depth Information
Lysosomal stability, macrofaunal diversity,
and PAHs
UNESCO-IOC GEEP/ICES
Oslo WS 1986
40
35
30
25
Lys. Stab.
Diversity
PAH
LangesundŒord
SKIEN
20
N
15
10
Skiens river
5
0
S1 S2 S3 S4
Sample site
0
1
2
3
4
5 km
PORSGRUNN
Gunnekleivljord
G FrierŒord
E
Lysosomal stability v macrofaunal diversity
35
Eidanger-
Œord
30
F
25
4D
D
BREVIK
20
4
15
3
y = 0.4118x + 15.866
R 2 = 0.8951
R = 0.946
P < 0.01
LangesundŒord
C
3C
D 2
2B
10
LANGESUND
B
5
0
A
1A
1
0 10 20 30 40
Lysosomal stability (min)
Langesund Bay
FIGURE 5.5
Macrofaunal diversity from four sites (A-D) and lysosomal stability (mean ± 95% CL, n = 10) in mussel Mytilus
edulis digestive gland cells from four sites (1-4), sampled along a pollutant gradient in Norway (indicated by
ΣPAHs in mussels), shows that mussels from the most contaminated site 4 are more similar to the cleanest mus-
sels at site 1 than are mussels from sites 2 and 3. Macrofaunal diversity H ʹ (mean ± 95% CL, n = 4) was measured
at adjacent sites (A-D). (C) Lysosomal stability is directly correlated with macrofaunal diversity. Lysosomal
stability is used here as an integrated indicator of cellular well-being, that can be used as a generic yardstick
for interpreting the responses of many biomarkers (Allen and Moore 2004; Moore et al. 2004a, b; 2006a). (Data
are derived from Gray, J.S. et al., Mar. Ecol. Prog. Ser. , 46, 151-165, 1988; and Moore, M.N., Mar. Ecol. Prog. Ser ., 46,
81-89, 1988. With permission.)
determine the extent to which their relative capabilities for up-regulation of autophagy
and the degradative (retrograde) component of protein turnover contribute to their ability
to survive natural and anthopogenic stress.
Consequently, it is probably a reasonable assumption that lysosomal autophagy does in
fact appear to provide a second line of defense against oxidative stress, and the capability
to effectively up-regulate this process is probably a significant factor contributing to the
ability of some organisms to tolerate stressful and polluted environments. However, fur-
ther studies are required to substantiate this claim.
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