The Effects of Kisspeptin on Gonadotropin Release in Non-human Mammals - Kisspeptin Signaling in Reproductive Biology - page 67

Table 4.2 Summary of the effect of repeated vs. continuous administration of kisspeptin-10 in different non-human mammals

Repeated administration Continuous administration

Species Route Dose Effect on LH Route Dose Effect on LH References

Rat ICV 1 nmol 10× inc ICV 7.5 nmol 2× inc to day 2, baseline day 4 [ 19 , 24 ,

54 ]

ICV 1 nmol 10× inc ICV 7.5 nmol 2× inc to day 5, baseline day 7

Hamster IP 1 nmol No reversal of seasonal gonadal

regression

ICV 0.25 nmol/h Restored testicular activity [ 15 , 26 ]

IP 1 nmol 3× inc in long day SC 0.2 nmol/h No reversal of seasonal

gonadal regression

SC 1 nmol 6× inc post last injection

Ewes IV 12.6 nmol 18× inc (fi rst injection), 10×

inc (second), 10× inc(third)

IV 12.4 nmol/h Sig inc at 2 h, placebo at 48 h [ 25, 67 ]

IV 15.3 nmol Inc frequency and amplitude IV 15.2 nmol/h 9× inc 5 h, 3× inc 10 h

IV 15.2 nmol/h 6 h 12.5%, 12 h 50%, 24 h

75% had LH surge

Goats IV 4.23 nmol/kg 11× inc (fi rst injection), 22×

inc (second), 15× inc (third)

[ 11 ]

Cow IV 500 pmol/kg Inc for 140 min, then decline [ 50 ]

Monkey IV 1.54 nmol 2× inc maintained for 48 h IV 7.7 nmol/h 2× inc to 1-2 h, then decline [ 16 , 21 ]

ICV intracerebroventricular; IP intra-peritoneal; IV intravenous; SC subcutaneous; Inc increase in plasma levels