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should also be taken into consideration. While considerable effort has been made to
untangle the individual neural pathways that may contribute to the stress suppres-
sion of reproductive function, revealing the true complexity of the networks in ques-
tion, a meaningful model of the complex interaction between stress and reproduction
is warranted. Perhaps future mathematical modeling will aid the assembly of the
components of the stress and reproductive systems brought to light to date and,
ultimately, provide a better understanding of the neural connectivity and signaling
mechanisms involved. In summary, kisspeptin signaling is a novel component of the
stress neurocircuitry implicated in the perturbation of reproductive development
and function under stress conditions.
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