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Fig. 20.3
Effects of restraint, insulin-induced hypoglycemia (IIH), and lipopolysaccharide (LPS)
stress on pulsatile LH secretion in ovariectomized estradiol (E
2
)-replaced rats. Representative
examples showing (
a
) normal LH pulses in a rat in the absence of restraint stress, (
b
) restraint (1 h)
stress-induced interruption of LH pluses, (
c
) normal LH pulses in a rat receiving an intravenous
injection of vehicle (0.3 mL saline), (
d
) the inhibitory effects of insulin-induced hypoglycemic
(insulin, 0.25 IU/kg in 0.3 mL saline i.v.) on LH pulses, (
e
) normal LH pulses in a rat receiving an
intravenous injection of vehicle (0.3 mL saline) for the immunological stress, and (
f
) the inhibitory
effects of LPS (0.5
g/kg in 0.3 mL saline i.v.) on LH pulses. (
g
) Summaries showing the effects
the three different stress paradigms on pulsatile LH secretion. *
P
< 0.05 vs. 2-h baseline control
period within the same treatment group;
n
= 8 per group (from Kinsey-Jones JS, Li XF, Knox AM,
Lin YS, Milligan SR, Lightman SL, et al. Corticotrophin-releasing factor alters the timing of
puberty in the female rat. J Neuroendocrinol. 2010 Feb;22(2):102-9. Reprinted with permission
from John Wiley & Sons)
μ
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