Biology Reference
In-Depth Information
Chapter 18
Circadian Regulation of Kisspeptin in Female
Reproductive Functioning
Lance J. Kriegsfeld
Abstract
Female reproductive functioning requires the precise temporal
organization of numerous neuroendocrine events by a master circadian brain clock
located in the suprachiasmatic nucleus. Across species, including humans, disrup-
tions to circadian timing result in pronounced defi cits in ovulation and fecundity.
The present chapter provides an overview of the circadian control of female repro-
duction, underscoring the signifi cance of kisspeptin as a key locus of integration for
circadian and steroidal signaling necessary for the initiation of ovulation.
Introduction
The circadian timing system universally coordinates central and peripheral physiol-
ogy, providing temporal structure to homeostatic regulation and ensuring that physi-
ological processes are maintained within optimal operating limits given changing
demands over the course of day and night. Because hormones enter the general
circulation, these signaling molecules have widespread infl uence over physiology
and behavior, and represent ideal communicators of timing information. As a result,
it is important to understand the means by which circadian rhythms in endocrine
secretions are generated and the functional consequences of this temporal commu-
nication for downstream target systems.
Converging lines of evidence indicate a critical role for circadian timing in suc-
cessful female reproduction across mammalian species, including humans. Women
with irregular work or sleep cycles, for example, exhibit reduced fertility [
1
] and an
L. J. Kriegsfeld , Ph.D. (
*
)
Department of Psychology and Helen Wills Neuroscience Institute, Neurobiology Laboratory,
University of California , 3210 Tolman Hall , 1650 , Berkeley , CA 94720-1650 , USA
e-mail: Kriegsfeld@berkeley.edu
Search WWH ::
Custom Search