Biology Reference
In-Depth Information
Fig. 15.2
Schematic representation of a coronal section of a rat brain at the arcuate level depicting
Tac2
and
Tacr3
expression.
SON
supraoptic nucleus;
BLAa
basolateral nucleus of the amygdala;
BMAa
basomedial nucleus of the amygdala;
MH
medial habenular nucleus;
LHA
lateral hypothala-
mus;
ZI
zona incerta;
VMH
ventromedial hypothalamic nucleus;
PVH
paraventricular hypotha-
lamic nucleus;
ARC
arcuate nucleus;
3V
third ventricle
receptors have been described previously, their potency of affi nity varies as follows:
NK1R, SP > NKA > NKB; NK2R, NKA > NKB > SP; and NK3R, NKB > NKA > SP
[
34
,
35
]. Within the context of this review, it is conceivable that this affi nity of NKB
for other tachykinin receptors, even though marginal, might compromise the inter-
pretation of the studies using NKB itself to decipher its putative roles in reproduc-
tive control. Thus, in order to overcome this limitation, the synthetic peptide
senktide, a highly selective and potent agonist of NK3R [
16
,
34
], has been system-
atically used in the majority of the experimental studies.
Search WWH ::
Custom Search