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or reducing the inhibitory tone of Dyn/KOR signaling by KOR antagonists
(Fig. 14.6d). The preliminary result detailed in this chapter (Fig.
14.2b
) partially
supports this proposition. There are several occasions in which insuffi cient LH
pulse frequency causes reproductive disorders, such as women with anorexia ner-
vosa [
138
], exercise amenorrhea [
140
], or hyperprolactinemia [
141
]. Our proposed
model implies that NKB agonists and KOR antagonists may hold promise as novel
therapeutic drugs to accelerate or improve gonadal activities via their ability to
enhance the GnRH pulse generator activity.
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