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Fig. 14.6
A speculative hypothesis for the role of KNDy neurons in the generation of pulsatile
GnRH release. (
a
) A population of KNDy neurons forms a neural network connected by their axon
collaterals (and/or dendrites). Through the reciprocal actions of NKB/NK3R and Dyn/KOR sig-
naling in the KNDy neuron network, episodic bursts are periodically generated, each of which, in
turn, induces pulsatile discharge of kisspeptin at the ME and hence, pulsatile GnRH release into
the portal circulation. (
b
) It is assumed that three components are involved in the generation of the
burst: the random activity of any neuron within the network that initiates the burst, NKB/NK3r
signaling that evokes synchronized bursting activities in the network, and Dyn/KOR signaling that
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