Biology Reference
In-Depth Information
Fig. 11.8
Kisspeptin and
Kiss1
expression are increased in the ARC of female and male
hpg
mice.
(
a
) Kisspeptin staining pattern in the ARC of both female and male WT mice (
left
of
dashed line
)
is dominated by densely stained fi bers that obscure kisspeptin-positive cell bodies (
white arrow-
heads
). In
hpg
mice (
right
of
dashed line
), kisspeptin immunoreactivity shows reduced fi ber stain-
ing and increased clusters of large, darkly stained cell bodies (
black arrowheads
). (
b
) Representative
dark-fi eld images of silver grain
Kiss1
mRNA signal as measured by ISH in the ARC of pubertal-
aged WT and
hpg
females (30 days) and males (45 days). Scale bar = 200 mm. Figure modifi ed
from Gill JC, Wang O, Kakar S, Martinelli E, Carroll RS, Kaiser UB 2010 Reproductive hormone-
dependent and -independent contributions to developmental changes in kisspeptin in GnRH-
defi cient hypogonadal mice. PLoS One 5:e11911
be controlled primarily by gonadal sex steroid feedback, whereas PND 16-18 males
have an additional mechanism of regulation of their ARC
Kiss1
neurons by unknown
non-gonadal factors. Whether this divergence between the sexes is due to a unique,
male-specifi c mechanism not present in similarly aged females or to sex differences
Search WWH ::
Custom Search