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Fig. 8.8
Effects of selected peptides on the elevation of intracellular calcium by KP-10 in
CHO/GPR54 cells. Graphs show antagonism of KP-10 stimulated calcium at 60 s.
Ant
is the
maximal antagonism achieved at micromolar concentrations. (
a
) Raw calcium transients for
KP-10 showing 60
dotted line
). (
b
) Quantifi cation of KP-10 calcium transients.
(
c
) Peptide 234 calcium transients showing antagonism of KP-10 stimulated calcium
(
d
) Quantifi cation of peptide 234 transients showing 89% antagonism. (
e
) Peptide 273 calcium
transient showing partial antagonism of KP-10 stimulated calcium by 63%. (
f
) Quantifi cation
of peptide 273 calcium transients. (
g
) Peptide 276 calcium transients showing complete antago-
nism of KP-10 stimulated calcium. (
h
) Quantifi cation of peptide 276 calcium transients show-
ing 100% antagonism
sec time point (
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