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Fig. 5.3
Resetting of the
GnRH pulse generator by
kisspeptin-10 in men.
(
a
) Predicted pulse pattern if
kisspeptin were to have no
effect on the timing of
endogenous pulses. Note that
actual pulse profi les show
more variability in pulse
intervals. (
b
) Predicted pulse
pattern if kisspeptin resets the
pulse generator, with a delay
in the appearance of the
next endogenous pulse.
(
c
) Observed pulse intervals.
Bars indicate means.
Reprinted with permission
from ref. [
11
]
Resetting of the GnRH Pulse Generator by Single-Bolus
Administration of Kisspeptin
The effects of kisspeptin-10 on GnRH pulse generation were determined in men by
examining the timing of endogenous LH pulses before and after kisspeptin admin-
istration [
11
]. Two contrasting models were tested. In one model, the “no resetting
model,” exogenous kisspeptin has no effect on the underlying GnRH pulse genera-
tor (Fig.
5.3
). The kisspeptin-induced GnRH pulse would therefore be an extra
pulse superimposed on top of the endogenous pulse pattern. One prediction of this
model is that the time interval between endogenous pulses should be unaffected by
kisspeptin administration. In particular, the interval from the endogenous pulse just
before the kisspeptin-induced pulse to the endogenous pulse immediately following
the kisspeptin-induced pulse (interval B in Fig.
5.3
) should be no different from the
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