Chemistry Reference
In-Depth Information
OH
O
R
H
2
N
O
N
HO
X
N
S
N
NH
O
Cl
NH
N
NH
Br
HO
O
NH
O
NH
OH
TDZD8
NH
O
O
R
NH
Indirubin-3'-oxime
BIO
(R=H)
O
N
Paullone
Kenpaullone
Alsterpaullone
Azakenpaullone
(R=H; X=C)
(R=Br; X=C)
(R=NO
2
; X=C)
(R=Br; X=N)
(R=Br)
Hymenialdisine
R
2
Flavopiridol
N
R
1
NH
N
N
NH
N
Aloisine A
Aloisine B
O
S
NH
[R
1
=OH; R
2
=(CH
2
)
3
CH
3
]
O
O
I
N
Br
F
NH
N
N
N
[R
1
=Cl; R
2
=CH(CH
3
)
2
]
NH
Compound 12
R
N
Pyrazolopyridine 18
NH
2
Pyrazolopyridine 34
N
NH
2
(R=2- furyl)
N
Cl
Cl
O
2
N
R
2
N
N
N
R
1
Cl
Cl
NH
N
N
NH
Compound 1
N
NH
N
NH
N
CT20026
O
NH
N
N
N
R
3
O
O
CHIR98014
(R
1
=NO; R
2
=NH
2
; R
3
=H)
CHIR99021
(R
1
=CN; R
2
=H; R
3
=CH
3
)
O
-
NH
NH
S
O
N
+
SU9516
O
N
NN
HH
ARA014418
O
O
NH
NH
O
O
NH
O
O
NH
O
O
N
N
N
N
N
N
N
O
N
N
(CH
2
)
3
(CH
2
)
3
N
N
N
S
O
O
O
O
( )
3
NHCH
2
O
N
Compound 46
Staurosporine
Compound 29
O
NH
O
Compound 5a
HO
O
N
NH
2
N
NH
O
O
NH
N
Cl
O
2
N
N
HN
R
1
TWS119
NH
OCH
3
N
OH
N
N
GF109203x
[R
1
=H; R
2
=N(CH
3
)
2
]
Ro318220
[R
1
=CH
3
; R
2
=SC(NH)NH
2
]
N
R
2
N
N
SB415286
N
N
N
NH
2
N
O
NH
N
N
O
NH
NH
O
N
N
COOH
Compound 8b
Br
Cl
Compound 1A
N
NH
Cl
Cl
Br
NH
S
Cl
I5
CGP60474
OH
O
Compound 17
Figure 2:
Structures of some of the most studied pharmacological inhibitors of GSK-3β.
No direct interactions are observed between the AMP-PNP phosphate groups and the nucleotide-binding loop of
GSK-3β. Instead the loop interacts with the phosphate groups through bridging water molecules and shields the
phosphate groups from the bulk solvent.