Chemistry Reference
In-Depth Information
Virus adsorption inhibitors
Virus co-receptor antagonists
Virus fusion inhibitors
HIV
Nucleocapsid protein
Zn-finger-targeted agents
Reverse transcriptase
inhibitors
HIV integrase inhibitors
Transcription
(transactivation) inhibitors
HIV protease inhibitors
Figure 3:
Life cycle of HIV (human immunodeficiency virus) and representation of the targets for anti-HIV drugs. Adapted from ref [12b].
The CBAs can be divided in two categories: lectins that specifically recognize glycan structures, and non-peptidic
small-size agents (Fig.
4
) that may have an efficient and often specific affinity for monosaccharide and/or
oligosaccharide structures [16]. Besides, various research groups have developed the synthesis and characterization
of synthetic CBAs.
CH
3
(A)
O
H
COOH
O
HO
CH
3
O
O
H
3
C
O
HO
O
CH
3
OH
O
OH
NH
O
Pradicimin A
O
HO
HO
HO
CH
3
(B)
O
H
COOH
O
HO
CH
3
O
O
H
3
C
OH
O
OH
HO
O
CH
3
O
O
H
HO
O
OH
OH
Figure 4:
Small-size non-peptidic carbohydrate-binding antigens (CBAs). Pradimicin A (
A
) and benanomicin A (
B
) are
produced
by
Actinomadura hibiscus
and
Actinomadura spadix
, respectively [16].
Benanomicin A
