Superoxide Dismutase and Glutathione Peroxidase in Dogs with Leishmaniasis Following Antimoniate Therapy - Veterinary Science - page 71

Chapter 12
Superoxide Dismutase and Glutathione
Peroxidase in Dogs with Leishmaniasis
Following Antimoniate Therapy

D. Britti, S. Sconza, G. Massimini, C. Civitella, A. Luciani, and L. Lavecchia

Abstract The effect of antimony treatment on antioxidative enzyme activities of
erythrocyte superoxide dismutase (SOD) and blood glutathione peroxidase
(GSHPx) and the associations between these enzyme activities and hematological
indices of anemia (pre- and posttreatment) was studied in dogs with leishmaniasis.
Twelve dogs with leishmaniasis before and after 60 days of therapy with
N -methylglucamine antimoniate were used. No significant differences in antioxi-
dant SOD and GSHPx activities or hematological indices, including HGB level,
RBC number, HCT, MCV, MCH, and MCHC, were detected between pre- and
post-antimony treatment. Results indicated that the presence or absence of previous
treatment with antimony had no statistically identifiable effects on antioxidant
enzyme activity or hematological indices.

Keywords Anemia • Canine visceral leishmaniasis • GSHPx • SOD • Therapy

Abbreviations

CanVL Canine visceral leishmaniasis
GSHPx Glutathione peroxidase
HCT

Hematocrit

HGB Hemoglobin

D. Britti ( * ) • L. Lavecchia
Dipartimento Medicina Sperimentale e Clinica, Universit` degli Studi di Catanzaro
“Magna Græcia”, Catanzaro, Italy
e-mail: [e-mail]
S. Sconza • C. Civitella • A. Luciani
Dipartimento Scienze Cliniche Veterinarie, University of Teramo, Teramo, Italy
G. Massimini
Medico Veterinario Libero Professionista, Ortona, Chieti, Italy