Biology Reference
In-Depth Information
Chapter 11
The Association Between N-Methylglucamine
Antimoniate and Pancreatitis in Dogs
with Leishmaniasis
A. Boari, M. Pierantozzi, G. Aste, S. Pantaleo, F. Di Silverio, G. Fanini,
L. Lorentzen, and D.A. Williams
Abstract In this study, the possible association between pancreatitis and treatment
with methylglucamine antimoniate (MA) in dogs with leishmaniasis was evaluated.
Of the 20 dogs included, three dogs showed clinical signs of pancreatitis. Abdomi-
nal ultrasound abnormalities suggestive of pancreatitis were observed in two dogs,
and increased cPLI was observed in four cases. The statistical results showed a low
probability of development of pancreatitis in patients treated with MA. However,
considering the possible recurrence of pancreatitis in four cases in our study, we
suggest that dogs treated with MA should be evaluated for pancreatitis, especially
when compatible clinical signs are present.
Keywords Dog Leishmaniasis Meglumine antimoniate Pancreatitis
Abbreviations
CanL Canine leishmaniasis
cPLI Canine pancreatic lipase immunoreactivity
MA Meglumine antimoniate
UP/UC Urinary protein/urinary creatinine ratio
A. Boari (
*
) M. Pierantozzi G. Aste S. Pantaleo F. Di Silverio G. Fanini
Dipartimento di Scienze, Cliniche Veterinarie, Teramo, Italy
e-mail:
aboari@unite.it
L. Lorentzen
IDEXX Laboratories Inc., Westbrook, ME, USA
D.A. Williams
Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL, USA
