Biology Reference
In-Depth Information
Chapter 9
Antibiotic Resistance Profiles in Relation
to Virulence Factors and Phylogenetic Groups
of Uropathogenic Escherichia coli Isolated
from Dogs and Cats
C. Tramuta, D. Nucera, P. Robino, S. Salvarani, and P. Nebbia
Abstract In this study, we assessed the relationship between antibiotic-resistance
profiles, virulence genotype, and phylogenetic group within a collection of
Escherichia coli obtained from dogs and cats with urinary tract infection (UTI).
Forty uropathogenic E. coli (UPEC) strains isolated from dogs ( n
30) and cats
¼
( n
10), formerly analyzed for virulence factors (VFs) and phylogenetic group,
were tested to detect antibiotic resistance for gentamicin (GM), trimethoprim-
sulfamethoxazole (SXT), nitrofurantoin (NT), enrofloxacin (ENO), cephalothin
(CF), cephoperazone (CFP), cefovecin (CVN), piperacillin (PIP), and amoxicillin-
clavulanic acid (AMC). A large number of isolates were resistant to cephalosporins,
especially to third-generation drugs, while the lowest level of resistance was found
to SXT. No statistically significant results were obtained ( P
¼
0.05). Concerning
antimicrobial resistance associated with VFs, only gene iutA showed an association
trend with multidrug resistance (MDR; P
>
0.055). Resistant strains were
distributed in all phylogenetic groups (57%, B2; 43%, non-B2), whereas E. coli
isolates susceptible to all antibiotics tested were associated with groups B2 (90%)
and D (10%).
¼
Keywords Antimicrobial resistance • Cats • Dogs • Escherichia coli • Phylogroup •
Urine • Urine virulence factors
C. Tramuta ( * ) • P. Robino • S. Salvarani • P. Nebbia
Dipartimento di Produzioni Animali, Epidemiologia ed Ecologia, Universit` di Torino, Torino,
Italy
e-mail: clara.tramuta@unito.it
D. Nucera
Dipartimento di Patologia Animale, Universit` di Torino, Torino, Italy
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