Biology Reference
In-Depth Information
pharmacologic treatment
.
Corticosteroids represent the treatment of choice for their
immunosuppressive properties. They have often been combined with azathioprine
or metronidazole for more aggressive treatment and to reduce the dosage needed
(Saxena et al.
1985
). Enrofloxacin was effective for the treatment of HUC and is
efficacious against infectious agents, which, as recently demonstrated, appear to be
responsible for the disease (Davies et al.
2004
). In one case of HUC, excellent
efficacy was inadvertently obtained with doxycycline. Doxycycline beyond antimi-
crobial activity inhibits the synthesis of nitric oxide found in high quantities in the
colon of subjects with chronic colitis (Amin et al.
1996
). Methotrexate, an antime-
tabolite of folic acid, has immunosuppressant and anti-inflammatory activities and
has been effectively used in a dog with protein-loss enteropathies and lymphocytic
enteritis that were unresponsive to steroids and cyclosporine (Yuki et al.
2006
).
These results allow consideration of possible therapeutic choices in the treatment of
IBD (Allenspach et al.
2007
). In conclusion, despite the difficulties in treating IBD,
the use of different therapeutic protocols and laboratory findings allows good
results to be obtained.
References
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one A, Steffan J, Strehlau G, Gashen F (2006) Pharmaco-
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ufenacht S, Sauter S, Gr
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