Biology Reference
In-Depth Information
Table 15.2 Thromboelastometer results for calves
Test
CT (s)
CFT (s)
MCF (mm)
Alfa (
)
In-TEM 270.6
66.1 (274.5)
173.5-360.3 (*)
64.9
13 (68)
74.9
10.3 (77)
77.2
2.4 (76.5)
45.9-81
62.1-81
74.6-81
Ex-TEM 70.3
9.9 (71)
55.7-81.7 (*)
99.8
19.3 (103.5)
68.2-122.1
77.7
3 (78)
72.9-81.3
74.1
3.1 (74.5)
70-78
Fib-TEM 73.9
6 (74.5)
65.6-81.7 (*)
183.1
105 (152.5)
66.6-374.9 (*)
30.1
4.1 (30.5)
75.9
3.5 (76.5)
69.9-79.7
24.6-36
Values are expressed as mean
SD (median), and 5th-95th percentile; * indicates significant
differences between adults and calves
15.4 Discussion
Compared to equine (Paltrinieri et al.
2008
) and canine (Wiinberg et al.
2005
;
Lubas et al.
2006
) tracings, bovine thromboelastograms present several distinctive
features. These differences are due to higher platelet counts and fibrinogen levels in
cattle (Kramer
2006
). CFT, which depends on initial platelet and fibrinogen activa-
tion, is short in cattle; MCF, which expresses maximum clot consistency and
depends on the interaction between platelets, fibrinogen, and factor XIII, is
increased in cattle. In our study, CT, which represents the clotting activity of
plasma factors, correlated positively to HCT. This observation is in line with a
previous study on canine blood (Smith et al.
2009
) but is in contrast to a study on
equine coagulation (Paltrinieri et al.
2008
). This correlation was also supported by
the shorter aPTT in the calves.
Analysis of the CV demonstrated good instrument precision, as previously
described in horses (Paltrinieri et al.
2008
). The lowest CVs were observed for
the na-TEM
®
profile, which represents the coagulation process without the use of
activators and is characterized by high individual variability.
Overall, TEM was found to be an accurate device that can be applied in the field
to study hemostasis in cattle.
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