Biology Reference
In-Depth Information
Chapter 14
Increased Oxidative/Nitrosative Stress in Bitches
with Several Tumors
R. Ciarcia, L. Navas, G.E. Granato, F. Fiorito, R. Russo, and S. Florio
Abstract Experimental and clinical data suggest that reactive oxygen species,
which cause no damage under physiological conditions, can cause cellular damage
at high concentrations and may play key roles in carcinogenesis. The aim of this
study was to evaluate the activities of catalase, superoxide dismutase, and glutathi-
one peroxidise, as well as the production of malondialdheyde and nitric oxide, in
bitches suffering adenocarcinoma, histiocytoma, and hemangiopericytoma. Data
showed that the levels of both malondialdheyde and nitric oxide were significantly
increased in both plasma and tissues. The decreased activities of antioxidant
enzymes and increased oxidative stress observed could be attributed to a reduction
in antioxidant defenses of the organism because of depleted defenses over time.
Keywords Catalase • Glutathione peroxidase • Superoxide dismutase • Tumor
Abbreviations
CAT Catalase
GPx Glutathione peroxidase
MDA Malondialdehyde
R. Ciarcia (
*
) • G.E. Granato • S. Florio
Dipartimento Strutture Funzioni e Tecnologie Biologiche, Universit
`
degli Studi di Napoli
“Federico II”, Naples, Italy
e-mail:
roberto.ciarcia@unina.it
L. Navas
Dipartimento di Scienze Cliniche Veterinarie, Universit` degli Studi di Napoli “Federico II”,
Naples, Italy
F. Fiorito • R. Russo
Dipartimento di Patologia e Sanit` Animale, Facolt` di Medicina Veterinaria, Universit` degli
Studi di Napoli “Federico II”, Naples, Italy
