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Figure 2-9. Hill's plot for the experimental measurements of Roughton et al.
and the theoretical values based on the MWC model.
PREDICTION BASED ON THESE CONSTANTS
The very large value of K indicates that at low oxygen pressure, hemoglobin
molecules are mostly in the T-state. Therefore, can be neglected
completely with respect to The ratio of is around 2.95 X 10 2 ,
so that can also be neglected with respect to , On the other hand,
the ratio of is around 12.22, i.e. they are of similar concentrations.
At high oxygen pressure, = 1.67 X and = 1.25 X
Therefore, and can be neglected. In short, according to the
MWC model, as the oxygen pressure increases, roughly around 50%
saturation, the T-state changes into the R-state (Fig. 2-10). This transition
is the most important prediction of the MWC model (Monod et al. , 1955).
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