Biology Reference
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with the three equilibrium constants clearly indicated. In the original paper,
Monod
et al.
(1965) made the following substitutions:
and
Therefore, percentage saturation satisfies the following equation:
A casual reader would consider this as a two-constant model having K and c
as equilibrium constants. However, is not and a third constant is
hidden in Comparing to some experimental results, Monod
et al.
found
that K was around
and c around
To estimate the values of and K of the MWC model based on the
experimental measurements of Roughton
et al.
(1955), we can again use the
very low and very high oxygen pressure approximations of y/(1-y).
In this
case, we have for very low oxygen pressure,
and for very high oxygen pressure,
using the approximate values of K and c determined by Monod
et al.
(1965).
The value of K can be determined using the requirement of
together with the values of
and
Thus, we get initially:
