Biology Reference
In-Depth Information
joining of a V-gene, a D-minigene and a J-minigene. Furthermore, the
addition of possible intervening sequences at their junctions is quite
frequent. They are known as N-segments, if G,C-rich (Alt and Baltimore,
1982), or P-segment, if A,T-rich (Lafaille
et al
., 1989). All of these occur in
the segment coding for the third complementarity determining region of the
heavy chain, CDRH3 (Fig. 1-9). The J-minigenes of heavy chain variable
region are located about 6 kb upstream from the 5'-end of the exon of C
H
1
of the
chain, IgM.
Figure 1-9
. Relative locations of CDR's in the heavy chain variable region
to the V-gene, D-minigene and J-minigene.
