Biology Reference
In-Depth Information
173
Figure 6-17.
Stereo view of CDRH2 of MOPC104E.
Indeed, the atomic coordinates of all non-hydrogen atoms are determined
(Hovis, 1982).
FUTURE THEORETICAL STRUCTURAL STUDIES
Even though the analytical method outlined above is quite complicated, it
makes use of the existing experimental data on three-dimensional structures
of reference proteins to predict possible three-dimensional configurations of
peptides of known amino acid sequences. However, much more work will
be required to understand how proteins fold into their active tertiary
structures with the information content of their amino acid sequences
(Anfinsen, 1973). In some simple cases, the amino acid sequences of
relatively small proteins in the proper environment may be sufficient to
determine their folding. For larger proteins, they may require the interaction
of other proteins or organelles. Theoretical analysis for the latter situation
will be very complicated.
