Biology Reference
In-Depth Information
153
Table 6-3. Amino acid sequences of seven neurohypophyseal hormones. All C-terminal Gly
are amidated. Cys 1 and Cys 6 form a disulfide bond.
1
2
3
4
5
6
7
8
9
Arginine-vasopressin
Cys
Tyr
Phe
Gln
Asn
Cys
Pro
Arg
Gly
Lysine-vasopressin
Cys
Tyr
Phe
Gln
Asn
Cys
Pro
Gly
Lys
Vasotocin
Cys
Tyr
Ile
Gln
Asn
Arg
Gly
Cys
Pro
Cys
Oxytocin
Tyr
Ile
Gln
Asn
Cys
Pro
Leu
Gly
Cys
Asn
Mesotocin
Tyr
Ile
Gln
Cys
Pro
Ile
Gly
Cys
Isotocin
Tyr
Ile
Ser
Asn
Cys
Pro
Ile
Gly
Glumitocin
Cys
Tyr
Ile
Ser
Asn
Cys
Pro
Gln
Gly
For these seven neurohypophyseal hormones listed in Table 6-3, the initial
choices of angles for the nine positions are given in Table 6-4,
together with various additional adjustments.
Table 6-4. Initial choices and adjustments of the
angles for neurohypophyseal
hormones.
Minimizing
Cys1-Cys6
distance
Initial
choices
Energy
minimization
Position
-135
0
,+166
0
-135
0
,+166
0
-152
0
,+140
0
1
-60
0
,-60
0
; -100
0
,+130
0
-60
0
,-60
0
-80
0
,-60
0
2
-66
0
,-11
0
-66
0
,-11
0
-67
0-
36
0
3
-78
0
,+142
0
-78
0
,+142
0
-98
0
,+149
0
4
-96
0
,+32
0
; -65
0
,-25
0
-96
0
,+32
0
-99
0
+34
0
5
-43
0
+147
0
-135
0
,+154
0
; -52
0
,+141
0
-52
0
,+141
0
6
-53
0
,-38
0
-53
0
,-21
0
-53
0
,-38
0
7
-59
0
,-46
0
-59
0
,-46
0
; -97
0
,+139
0
-72
0
,-13
0
8
+81
0
,-30
0
+81
0
,-30
0
+82
0
,+69
0
9
