Biomedical Engineering Reference
In-Depth Information
Figure 3.15.
Three-dimensional depiction of cell density field during streaming
in a coupled signaling-chemotaxis model. Cells are modeled as points that move in
response to both chemical signals (arising from cAMP relay waves) and adhesive
forces of other cells. Each unit on the axes corresponds to a computational point
and thus a cell. Assuming a typical cell size of 10
μ
m along the horizontal direction,
and 2 micron along the vertical direction, the computational domain represents
500x500x40
μ
m. Many researchers have obtained similar results using a variety of
models; one must therefore conclude that streaming is a generic occurrence in this
coupled system, independent of fine details such as the precise emission geometry.
there is still uncertainties regarding molecular details. Wavefield evolution
models and related efforts to predict streaming patterns still need to be com-
pared more quantitatively with experiments, but we expect no real surprises
as we refine our thinking. On the other hand, there are still fundamentally un-
resolved questions regarding single-cell chemotactic decision-making. Finally,
there are only a few initial attempts at modeling the actual mechanics of
amoeboid motion (and none applied specifically to Dicty), not to mention the
coupling between this complex process and the signaling system.
As should be evident from our discussion, ongoing progress requires active
collaboration between biologists and physicists, both experimental and theo-
retical. It is very exciting to see how the tools of complex-systems physics can
help unravel living behavior, and it is our contention that Dicty remains one
of the best examples of progress in this newly emerging interdisciplinary field.
