Protein Structure Modeling and Docking at the Swiss Institute of Bioinformatics - Bioinformatics: A Swiss Perspective - page 238

to provide richer functionality directly within the web page with respect
to visualization and structure comparisons, annotations, and cross-
references with other resources and tools; and provide direct seamless
workflows for the most relevant structure-related questions in biomedical
research. The following fictive example may illustrate the possibilities of
such an integrated web-based workflow at the SIB: Starting from a pro-
tein sequence in the UniProt 121 database on ExPASy, a 3D model can be
constructed using SWISS-MODEL Workspace. 19 Annotated SNPs and
known mutations can be mapped on the model and visualized. If the
model is of sufficiently high quality, ionization states and partial charges
could be assigned to prepare the model as a target molecule for docking
of a specific ligand 128 or for virtual screening. 104,108
Although the gap between the number of predicted protein
sequences and experimentally determined protein structures will remain
large for the foreseeable future, we will continue our efforts to bridge this
gap by developing integrated and easy-to-use protein modeling resources
such as SWISS-MODEL and the Protein Model Portal.
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