Chemistry Reference
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indispensable role in the control of distance-mediated signal transduction and in
turn the operation of these FRET-based sensors. The differences in such interac-
tions in the absence and presence of target species determine the signal-to-noise
ratio and the detection reliability. Noteworthy is that different pairs of CPEs and
biomolecules interact with each other differently according to their charge sign and
hydrophobic natures. In addition, to obtain high FRET efficiency, the pair of CPE
and acceptor fluorophore should be chosen in detailed consideration of their energy
level alignment, molecular orientation, spectral overlap, distance and complex
structure. It is believed that more and more biosensors based on FRET between
CPEs and organic dyes will be established and brought into practical applications.
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