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Fig. 21 (a) Chemical structure of the sodium salt of the anionic pentameric thiophene derivative, p-FTAA. (b) Fluorescence image of p-FTAA labeled A
b
deposits in brain tissue from a transgenic mouse model with AD pathology. (c) Emission spectrum of p-FTAA bound to A
b
deposits. (d) Ex vivo fluorescence
image of p-FTAA-labeled prion deposits in mice infected with mouse-adapted sheep scrapie, mSS (
left
), or mouse-adapted chronic wasting disease, mCWD
(
middle
), that have been intracerebrally injected with p-FTAA. Typical emission spectra from p-FTAA (
right
) upon binding to mCWD (
blue
) or mSS (
red
)
deposits.
Scale bars
represent 50
m
m. (e) High resolution fluorescence images of human brain tissue with AD pathology showing an overview of the interplay
between A
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