Chemistry Reference
In-Depth Information
HO
O
O
HO
OH
O
n
a
−
CD
: n = 6
b
−
CD
: n = 7
g
−
CD
: n = 8
Fig. 3 Spatial structure of
b
-cyclodextrin (
b
-CD)
[
20
] or acetylene dyes [
21
] given the unique nature imparted by their structure. As a
result, these molecules have found a number of applications in different fields. The
formation of guest-host complexes between dye molecules and CD macrocycles
leads to certain improvements of the dyes' physicochemical properties.
Cyanine dye-CD complexes were first reported by Kasatani et al. in 1984 using
3,3
0
-diethyloxadicarbocyanine iodide (DODC)[
22
]. It was found that this dye
formed complexes with
-CD. Later, they demonstrated
the same tendency with cyanines 1 and 2 [
23
]. It was shown that inclusion of
cyanine dyes in
b
- and
g
-CDs but not with
a
-CD helps to inhibit dimer formation as well as to
enhance the photostability of these cyanines, thereby enhancing the dyes' utility as
a fluorescent probe [
7
,
24
].
b
-CD and Me-
b
R
R
X
X
O
O
N
R
N
N
N
n
R
E
E
1
2
R = Cl, Ph
n = 1-3; X = O, S, CMe
2
; R = Me, Et, -(CH
2
)
3
SO
3
H
R
1
R
1
N
N
R
N
R
2
N
n
(H
2
C)
R
3
3
β
-CD
H
O
3a
: R
1
= H, R
2
= Me, R
3
= (CH
2
)
2
COOH
4
4a
: R = Me, n = 2
4b
3b
: R
1
= H, R
2
= Me, R
3
= (CH
2
)
5
COOH
: R = Me, n = 5
: R
1
= H, R
2
= Me, R
3
= (CH
2
)
10
COOH
3c
4c
: R = Me, n = 10
3d
: R
1
= H, R
2
= CH
2
CHMe
2
, R
3
= (CH
2
)
5
COOH
4d
: R = CH
2
CHMe
2
, n = 2
Cy5
: R
1
= SO
3
H, R
2
= Et, R
3
= (CH
2
)
5
COOH
Search WWH ::
Custom Search