Biomedical Engineering Reference
In-Depth Information
Table 5.3
The most relevant clinical trials in stem cell therapy
Trial
N (Treated/
Control)
Cell
type
Delivery
method
Outcomes
Menasche et al.
2003[
177
]; Hagege
et al. 2006 [
178
]
10/0
SkM
CABG
: regional wall motion; :
global LVEF
Smits et al. 2003 [
179
]
5/0
SkM
TEc
: regional wall motion; :
global LVEF
Ince et al. 2004 [
180
]
6/6
SkM
TEc
: global LVEF
Siminiak et al. 2004 [
181
]
10/0
SkM
TEp w/o
CABG
: regional wall motion; :
global LVEF
Chachques et al. 2004
[
182
]
20/0
SkM
TEp w/o
CABG
: regional wall motion; :
global LVEF; : tissue
viability
Dib et al. [
97
]
30/0
SkM
TEp w/o
CABG
: regional wall motion; :
global LVEF; : tissue
viability; ; ESV; ; EDV
Siminiak et al. 2005 [
183
]
9/0
SkM
TC
Symptoms improved
Gavira et al. [
110
]
12/14
SkM
TEp ? CABG : regional wall motion; :
global LVEF; : tissue
viability; : perfusion
Biagini et al. 2006 [
184
]
10/0
SkM
TEc
: regional wall motion; ;
ESV; & EDV
MAGIC/Menasche et al.
[
94
]
67 (2CD)/30
SkM
TEp ? CABG & global LVEF; ; ESV
CAUSMIC/Dib et al.
[
185
]
23
SkM
TEc
Improvement in heart failure
symptoms;
SEISMIC/Duckers
et al.[
186
]
40
SkM
TEc
& LVEF; improvement in
patient symptoms
Strauer et al. 2002 [
187
]
10/10
BMC
IC
: regional wall motion; ;
ESV; & EDV; :
perfusion; ; infarct size
TOPCARE-AMI/ et al.
[
188
]; Britten et al.
2003 [
189
];
Schachinger et al.
2004 [
190
]
19/11
BMC/
CPC
IC
: regional wall motion; ;
ESV; & EDV; ; infarct
size; improvement in
global LVEF
Fernandez-Aviles et al.
2004 [
191
]
20/13
BMC
IC
: thickness of infarct wall; ;
ESV; & EDV
Perin et al. 2004 [
192
]
11/9
BMC
TEc
Improvement in myocardial
perfusion
Erbs et al. [
193
]
13/13
BMC
IC
; infarct size
Patel et al. 2005 [
194
]
10/10
BMC
dMI
Improvement in LV function
BOOST I/Wollert et al.
[
195
]; Schaefer 2006
[
196
]
30/30
BMC
IC
; infarct size; improvement
in global LVEF
LEUVEN-AMI/Jannsens
et al. 2006 [
197
]
66
BMC
IC
; infarct size; : tissue
viability; : perfusion; :
regional contractility; &
LVEF
(continued)
