Biomedical Engineering Reference
In-Depth Information
Chapter 9
Pancreatic Regeneration in the Face of
Diabetes
Zeeshan Ahmad
Abstract Diabetes affects millions of people worldwide and the incidence is
growing day by day. Hyperglycemia, the main culprit in this disease can be
managed through the use of intensive insulin therapy and/or oral hypoglycemic
agents. However, the ailment is not cured and leaves the patients dependent on
treatment for the rest of their lives. Therefore, maintaining an ideal euglycemic
state without external intervention is the much-awaited cure for diabetes. It can be
achieved through the replacement of lost b cells with new functional b cells or by
inducing beta cell regeneration. This chapter reviews the literature regarding
various approaches being used today or those expected to be used for this in future.
Abbreviations
Arx
Aristaless-related homeobox
BCG
Bacillus Calmette-Guérin
BMP
Bone Morphogenetic Protein
CCK
Cholecystokinin
CFA
Complete Freund's Adjuvant
CK
Cytokeratin
DPP
Dipeptidyl Peptidase
DPSCs
Dental Pulp Stem Cells
EGF
Epidermal Growth Factor
EGFP
Enhanced Green Fluorescent Protein
ES cells
Embryonic Stem cells
FGF
Fibroblast Growth Factor
GABA
c-Aminobutyric acid
