Biomedical Engineering Reference
In-Depth Information
[
128
]. In support of this idea, injection of MSCs in the mouse animal model of
collagen-induced arthritis (CIA) has prevented severe arthritis and lowered the
serum level of inflammatory cytokines [
129
].
7.11 Conclusion
MSCs possess characteristics that render them appropriate cell candidates for
regenerating incurable or difficult to cure bone and cartilage diseases. In the past,
several attempts have been made to exploit the capability of MSCs to cure disorders
such as large bone defects, distraction osteogenesis, osteonecrosis, nonunion
fractures, OA, hypophosphatasia, cartilage defects following trauma, OA, and RA.
All these applications are in the trial phase and further investigations are needed to
confirm the beneficial effects of MSCs that have been reported by authors worldwide,
before MSC-based cell therapy becomes a routine therapeutic procedure.
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