Chemistry Reference
In-Depth Information
5 Future Perspectives
Recent developments of DNP have shown great potential in solid-state and liquid-
state NMR spectroscopy and in MRI. As promising as DNP is, the future develop-
ment of hyperpolarization transition may require great improvement in the following
aspects:
1. Development of new instrumentation in DNP. The new design of instruments
for DNP should be able to couple conveniently with the current high field NMR
spectrometers.
2. New DNP methods should be able to overcome the limitation of the very short
lifetime of the hyperpolarization, and should be integrated into the currently
available solid-state and liquid-state NMR experiments.
3. Development of new chemical agents to transfer effectively magnetization
of electrons to nuclei for the problem orientated applications in NMR spectros-
copy and MRI.
We expect a new wave of DNP research in the next few years, which may result
in unprecedent breakthroughs of these techniques, consequently allowing us to
detect diseases early in a non-invasive way and to study biomolecules in much
lower concentrations.
Acknowledgements This research work was supported by grants from Hong Kong Research
Grants Council (RGC664109, RGC775508, and RGC776509), AoE/M-06/08, TUYF10SC03,
SEG/CUHK09, SEG_HKUST06, and HKUST Research Fund.
References
1. Overhauser AW (1953) Phys Rev 92:411-415
2. Carver TR, Slichter CP (1953) Phys Rev 92:212-213
3. Carver TR, Slichter CP (1956) Phys Rev 102:975-980
4. Abragam A, Proctor WG (1958) Phys Rev 109:1441-1448
5. Duckett SB, Sleigh CJ (1999) Prog Nucl Magn Reson Spectrosc 34:71-92
6. Bargon JNaJ (1997) Prog Nucl Magn Reson Spectrosc 31:293-315
7. Navon G, Song Y-Q, R˜˜m T, Appelt S, Taylor RE, Pines A (1996) Science 271:1848-1851
8. Fitzgerald RJ, Sauer KL, Happer W (1998) Chem Phys Lett 284:87-92
9. Cherubini A, Payne GS, Leach MO, Bifone A (2003) Chem Phys Lett 371:640-644
10. Pavlovskaya GE, Cleveland ZI, Stupic KF, Basaraba RJ, Meersmann T (2005) Proc Natl Acad
Sci USA 102:18275-18279
11. Loening NM, Rosay M, Weis V, Griffin RG (2002) J Am Chem Soc 124:8808-8809
12. Hofer P, Parigi G, Luchinat C, Carl P, Guthausen G, Reese M, Carlomagno T, Griesinger C,
Bennati M (2008) J Am Chem Soc 130:3254-3255
13. Maly T, Debelouchina GT, Bajaj VS, Hu KN, Joo CG, Mak-Jurkauskas ML, Sirigiri JR, van
der Wel PCA, Herzfeld J, Temkin RJ, Griffin RG (2008) J Chem Phys 128:052211
14. Armstrong BD, Han S (2007) J Chem Phys 127:104508
15. Grucker D, Guiberteau T, Eclancher B, Chambron J, Chiarelli R, Rassat A, Subra G, Gallez B
(1995) J Magn Reson B 106:101-109
