Biology Reference
In-Depth Information
CONCLUSION
By combining the array data presented here with the information from the previous
QTL study, it may be possible to identify the best candidates for the clinical features
and increased resistance to PRV infection. In addition, further studies and functional
analysis of these candidates will broaden the scientific understanding of PRV infec-
tion, provide biomarkers to use as diagnostic tools, and may also lead to the develop-
ment of novel antiviral treatments and/or the application of marker assisted selection
for disease resistance.
KEYWORDS
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Central nervous system
•
Oligonucleotide
•
Pseudorabies virus
•
Varicellovirus
AUTHORS' CONTRIBUTIONS
J. F. Yuan, S. J. Zhang, and O. Jafer performed the microarray experiments. R. A.
Furlong and O. E. Chausiaux contributed towards the data analysis. G. H. Zhang car-
ried out animal experiments and sample collection. C. A. Sargent and N. A. Affara
contributed intellectually to the study, and to manuscript preparation. All authors have
read and approved the final manuscript.
ACKNOWLEDGMENTS
We thank Anthony Brown, Peter Ellis, Gina Oliver, Claire Quilter, Junlong Zhao, and
Rui Zhou for their skilled technical assistance. Financial assistance from the 863 High
Technology and Development Project of China (2006AA10Z195, 2007AA10Z152),
Chinese projects (2006BAD14B08-02, 2006BAD04A02-11), Hubei project
(2006CA023), Wuhan project (20067003111-06), and National Project of China
(04EFN214200206) is greatly appreciated.
