Biology Reference
In-Depth Information
mhp
gene families [32] (see Figure 1, cluster 3). These pathways are also phylogenom-
ically related to the biphenyl/polychlorinated biphenyl (Bhp) degradation pathways
in
Pseudomonad
species [32]. For
Comamonas
testosteroni
, this pathway is thought
to be associated with lignin degradation [31]. Hydroxyphenyl propionate (HPP), an
alkanoic acid of phenol, is the substrate for
Mhp
, and is also produced by animals in
Figure 1.
Aerobic degradation of aromatic compounds: multiple
Mhp
-like dioxygenase clusters. Each
of the six
mhp
-like gene clusters in the
D. aromatica
genome is depicted. Recent gene duplications
between individual proteins are shown by a purple connector between duplicates. Naming
convention was chosen for simplicity and consistency, and names all proteins paralogous to a given
Mhp
protein with the
Mhp
name (MhpABCDEF or R), but does not imply enzymatic specificity for
the substrates listed here-in, though the general enzymatic reaction is highly likely to be conserved.
The
Mhp
: meta cleavage of HPP, (hydroxyphenyl)propionate. The
Mhp
A, 3HPP hydroxylase;
Mhp
B,
DHPP 1,2-dioxygenase;
Mhp
C, 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase;
Mhp
D, 2, deto-4-
pentenoate hydratase;
Mhp
E, 4-hydroxy-2-ketovalerate aldolas;
Mhp
F, acetaldehyde dehydrogenase.
