Chemistry Reference
In-Depth Information
to establish a human intake with negligible risk, which is called the ADI. The NOAEL is normally
derived from chronic (long-term) studies in rodents. The ADI is usually calculated as the NOAEL
(in mg/kg body weight per day) divided by a 100-fold uncertainty factor, which allows for possible
species differences and human variability (Renwick et al. 2003; Renwick 2009).
Low-calorie sweeteners are often added to foods as mixtures or blends because mixtures can
provide an improved taste proile, and in some cases, the combination is sweeter than predicted
from the amounts present. The only property that is common to all low-calorie sweeteners is their
activity at the sweet-taste receptor. They do not share similar metabolic fates or high-dose effects.
Therefore, no interactions would arise if different low-calorie sweeteners are consumed together
in a blend (Groten et al. 2000), and each sweetener would be as safe as if it were consumed alone.
reFereNCeS
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